Endocrine Abstracts

Background: During the COVID-19 outbreak, there are rising concerns about long-term complications of COVID-19. On the other hand, discitis is a rare neurologic diagnosis, often delayed or missed due to the rarity of the disease. Patients usually present at an average age of 69 years with a history of diabetes or with a systemic infection. The lumbar spine is the most frequent site of infection (54%), and the cervical is the least at 10%. This is a case of post-COVID-19, diabet...

Introduction: Hyponatremia (defined as a serum sodium level <135 mmol/l), is seen in in 15–30% in hospital setting, especially in intensive care units. Certain drugs (e.g.Thiazides diuretics) used in everyday clinical practice, may induce hyponatremia, more frequently in elder women.Case report: A 76-year-old woman presented at emergency unit with complaints: physical weakness, nausea, vomiting, extreme fatigue and abdominal pain. She was under ...

Introduction: Adrenomyeloneuropathy (AMN) is a form of X-linked adrenoleukodystrophy (X-ALD) a rare inherited disorder (estimated prevalence 1:20 000 to 1:50 000) characterized by the accumulation of very long chain fatty acids (VLCFA) and affects mainly the nervous system white matter and the adrenal cortex and nearly 100% penetrance in males. Widely varying phenotypes and prognoses often co-occur in a single kindred.Methods: We report a case diagnosed ...

Background: Latent autoimmune diabetes of adults (LADA) constitutes 5–10% of the population with diabetes. Early diagnosis of LADA prevents misdiagnostification of type 2 diabetes and helps in the optimal treatment of patients, while maintaining a residual B cell function and delaying the time of their destruction.Aim: The aim of the study identifying groups with higher risk of LADA in an Albanian population.Material and metho...

Recent studies using the viral transneuronal tracing technique allowed to reveal brain neurons synaptically connected with the adrenal gland, via specific infections within functionally related chains of neurons. The aim of the present study was to investigate whether cerebral neurons involved in the innervation of the adrenal gland exhibit asymmetry or not. In order to label simultaneously the supraspinal neurons connected with the right- and left-sided adrenal glands, dual-v...

Introduction: Primary hyperparathyroidism (PHPT) is a rare disorder among young adults. Classic manifestations of PHPT, such as nephrocalcinosis, nephrolithiasis, are rarely seen today.Case report: We refer the case of a young male, 25 years old, presented in emergency unit with: headaches, lumbago, epigastric pain, weight loss (5 kg during six last months), polydipsia-polyuria. Medical history: He has been diagnosed with nephrolithiasis and gastritis a ...

Background: Diabetes-related ketoacidosis (DKA) is a common and potentially life threatening complication in people with diabetes. Despite national and international guidelines, interhospital guideline variation and mismanagement during admission are important contributory factors to increased DKA duration and length of stay.Aim: To establish a common DKA registry to identify gaps in management, assess outcomes and share best practises across centres.</p...

Introduction: Hybrid closed loop (HCL) systems are made up of continuous glucose monitoring (CGM) sensor, an algorithm that receives the readings from the CGM and an insulin pump able to deliver variable insulin doses according to the information received from the other two parts. Predictive low-glucose suspend (PLGS) insulin pump is able to stop the administration of insulin before hypoglycemia occurs. These new technologies are meant to improve the quality of life and help t...

Anaplastic Thyroid Carcinoma (ATC) is the most aggressive thyroid gland malignancy characterized by undifferentiated morphology. It has been suggested that cancer stem cells (CSCs) might play a central role in ATC. Previously on the basis of CD133 positivity, our group suggested that CD133+ cancer stem cells (CSCs) might play a central role in ATC. Here we analyzed a panel of different stem cell markers in order to identify a peculiar CSC pattern in ATC....

Abstract: Obesity results from an imbalance between caloric intake and energy expenditure. Specialized neurons of the hypothalamus coordinately control the integration between feeding and thermogenesis and a defective regulation of these parameters contribute to the progressive accumulation of body fat. Recent studies have revealed that at least part of hypothalamic dysfunction contributing to the development of obesity results from the activation of a local inflammatory respo...